abstract：BACKGROUND:Approximately 50 million people (60 %) live in malaria risk areas in Ethiopia, at altitudes below 2000 m. According to official data, 60-70 % of malaria cases are due to Plasmodium falciparum, and 40-30 % by Plasmodium vivax. The species Plasmodium ovale was detected in 2013 in the northwest of the country, ...

journal_title：Malaria journal

authors： Díaz PB,Lozano PM,Rincón JM,García L,Reyes F,Llanes AB

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Defining the number and location of sprayable structures (houses) is foundational to plan and monitor indoor residual spray (IRS) implementation, a primary intervention used to control the transmission of malaria. Only by mapping the location and type of all sprayable structures can IRS operations be planned...

journal_title：Malaria journal

authors： Kamanga A,Renn S,Pollard D,Bridges DJ,Chirwa B,Pinchoff J,Larsen DA,Winters AM

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDT) and real-time PCR (qPCR) assays are sensitive for diagnosing malaria, but because they detect antigen and DNA, respectively, positivity may not reflect active infection. Performance characteristics of RDT and qPCR in Plasmodium falciparum positive specimens were evaluated over ti...

journal_title：Malaria journal

authors： Phuong M,Lau R,Ralevski F,Boggild AK

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:Universal coverage with long-lasting insecticidal mosquito nets (LLIN) or indoor residual spraying (IRS) of houses remain the primary strategies for the control of mosquito vectors of malaria. Pyrethroid resistant malaria vectors are widespread throughout sub-Saharan Africa and new insecticides with differen...

journal_title：Malaria journal

authors： Oxborough RM,N'Guessan R,Kitau J,Tungu PK,Malone D,Mosha FW,Rowland MW

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:A deeper understanding of the ecology and small-scale heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated in five villages in close proximity to a hydro-agri...

journal_title：Malaria journal

authors： Diakité NR,Guindo-Coulibaly N,Adja AM,Ouattara M,Coulibaly JT,Utzinger J,N'Goran EK

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:The study of the biology, transmission and pathogenesis of Plasmodium vivax is hindered due to the lack of a robustly propagating, continuous culture of this parasite. The current culture system for P. vivax parasites still suffered from consistency and difficulties in long-term maintenance of parasites in c...

journal_title：Malaria journal

authors： Roobsoong W,Tharinjaroen CS,Rachaphaew N,Chobson P,Schofield L,Cui L,Adams JH,Sattabongkot J

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...

journal_title：Malaria journal

authors： Moreno M,Saavedra MP,Bickersmith SA,Lainhart W,Tong C,Alava F,Vinetz JM,Conn JE

更新日期：2015-07-30 00:00:00

abstract：BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...

journal_title：Malaria journal

authors： Reiling SJ,Rohrbach P

更新日期：2015-07-15 00:00:00

abstract：:The potential use of ivermectin as an additional vector control tool is receiving increased attention from the malaria elimination community, driven by the increased importance of outdoor/residual malaria transmission and the threat of insecticide resistance where vector tools have been scaled-up. This report summariz...

journal_title：Malaria journal

authors： Chaccour CJ,Rabinovich NR,Slater H,Canavati SE,Bousema T,Lacerda M,Ter Kuile F,Drakeley C,Bassat Q,Foy BD,Kobylinski K

更新日期：2015-06-11 00:00:00

abstract：BACKGROUND:In many low-income countries, the private commercial sector plays an important role in the provision of malaria treatment. However, the quality of care it provides is often poor, with artemisinin combination therapy (ACT) generally being too costly for consumers. Decreasing ACT prices is critical for improvi...

journal_title：Malaria journal

authors： Patouillard E,Hanson K,Kleinschmidt I,Palafox B,Tougher S,Pok S,O'Connell K,Goodman C

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS:Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-bi...

journal_title：Malaria journal

authors： Teo A,Hasang W,Randall LM,Unger HW,Siba PM,Mueller I,Brown GV,Rogerson SJ

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Molecular tools for detection of low-density asymptomatic Plasmodium infections are needed in malaria elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic malaria in Zanzibar. ...

journal_title：Malaria journal

authors： Morris U,Khamis M,Aydin-Schmidt B,Abass AK,Msellem MI,Nassor MH,González IJ,Mårtensson A,Ali AS,Björkman A,Cook J

更新日期：2015-05-17 00:00:00

abstract：BACKGROUND:In Uganda, treatment of clinical malaria and intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) are common during pregnancy. As a result, both formal and informal reports from antenatal sources suggest possible misuse of SP for malaria treatment among pregnant women. The objective of this...

journal_title：Malaria journal

authors： Odongo CO,Bisaso KR,Kitutu F,Obua C,Byamugisha J

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:The resistance of malaria parasites to sulphadoxine-pyrimethamine (SP) in 2007 led to the Malawi Ministry of Health changing to artemether-lumefantrine (AL) as first-line for uncomplicated malaria treatment. This study determined the efficacy and safety of AL for the treatment of uncomplicated Plasmodium fal...

journal_title：Malaria journal

authors： Dambe R,Sande J,Ali D,Chilima B,Dodoli W,Michelo C,Malenga G,Phiri KS

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin wer...

journal_title：Malaria journal

authors： Antonio-Nkondjio C,Tene Fossog B,Kopya E,Poumachu Y,Menze Djantio B,Ndo C,Tchuinkam T,Awono-Ambene P,Wondji CS

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission settings or in populations on the cusp of elimination. However, most of studies are designed to contro...

journal_title：Malaria journal

authors： Sepúlveda N,Drakeley C

更新日期：2015-04-03 00:00:00

abstract：BACKGROUND:Current available malaria diagnostic methods each have some limitations to meet the need for real-time and large-scale screening of asymptomatic and low density malaria infection at community level. It was proposed that malaria parasite-specific low molecular-weight metabolites could be used as biomarkers fo...

journal_title：Malaria journal

authors： Park YH,Shi YP,Liang B,Medriano CA,Jeon YH,Torres E,Uppal K,Slutsker L,Jones DP

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...

journal_title：Malaria journal

authors： Laman M,Benjamin JM,Moore BR,Salib M,Tawat S,Davis WA,Siba PM,Robinson LJ,Davis TM

更新日期：2015-03-21 00:00:00

abstract：BACKGROUND:Helminths and malaria are among the most prevalent infectious diseases in the world. They both occur in tropical area where they often affect the same populations. There are studies suggesting an effect of helminths on malariometric indices. For example, malaria attacks as well as disease severity has been s...

journal_title：Malaria journal

authors： Ateba-Ngoa U,Adegnika AA,Zinsou JF,Kassa Kassa RF,Smits H,Massinga-Loembe M,Mordmüller B,Kremsner PG,Yazdanbakhsh M

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Invasion of host erythrocytes by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion involves recognition events between erythrocyte receptors and ligands on the merozoite, the invasive blood form of the parasite. Identifying and characterizing host-parasite interactions is impeded by t...

journal_title：Malaria journal

authors： Saetear P,Perrin AJ,Bartholdson SJ,Wanaguru M,Kussrow A,Bornhop DJ,Wright GJ

更新日期：2015-02-21 00:00:00

abstract：BACKGROUND:Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, the drug resistance profile of current and previous first-line anti-malarials in Kenya was assessed w...

journal_title：Malaria journal

authors： Shah M,Omosun Y,Lal A,Odero C,Gatei W,Otieno K,Gimnig JE,ter Kuile F,Hawley WA,Nahlen B,Kariuki S,Walker E,Slutsker L,Hamel M,Shi YP

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Resistance to multiple classes of insecticides has been detected in the malaria vector Anopheles albimanus in northwest Peru. Acetylcholinesterase (AChE) insensitivity has previously been associated with resistance to organophosphate (OP) and carbamate (CA) insecticides in arthropods. A single point mutation...

journal_title：Malaria journal

authors： Liebman KA,Pinto J,Valle J,Palomino M,Vizcaino L,Brogdon W,Lenhart A

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (mAbs) are essential tools in biological research, diagnosis and therapy, and are conventionally produced in murine hybridoma cell lines. Professional applications of mAbs depend on the steady supply of material. Because hybridoma cultures can stop producing the antibody or even die, pr...

journal_title：Malaria journal

authors： Kapelski S,Boes A,Spiegel H,de Almeida M,Klockenbring T,Reimann A,Fischer R,Barth S,Fendel R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...

journal_title：Malaria journal

authors： Gore-Langton GR,Mungai J,Alenwi N,Abagira A,Bicknell OM,Harrison R,Hassan FA,Munga S,Njoroge F,Juma E,Allan R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...

journal_title：Malaria journal

authors： Pfeil J,Heine JF,Mueller AK

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:Based on routine health facility case data, Rwanda has achieved a significant malaria burden reduction in the past ten years. However, community-based malaria parasitaemia burden and reasons for continued residual infections, despite a high coverage of control interventions, have yet to be characterized. Mea...

journal_title：Malaria journal

authors： Kateera F,Mens PF,Hakizimana E,Ingabire CM,Muragijemariya L,Karinda P,Grobusch MP,Mutesa L,van Vugt M

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock o...

journal_title：Malaria journal

authors： Mayagaya VS,Nkwengulila G,Lyimo IN,Kihonda J,Mtambala H,Ngonyani H,Russell TL,Ferguson HM

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...

journal_title：Malaria journal

authors： Abdallah JF,Okoth SA,Fontecha GA,Torres RE,Banegas EI,Matute ML,Bucheli ST,Goldman IF,de Oliveira AM,Barnwell JW,Udhayakumar V

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Complex malaria infections are defined as those containing more than one genetically distinct lineage of Plasmodium parasite. Complexity of infection (COI) is a useful parameter to estimate from patient blood samples because it is associated with clinical outcome, epidemiology and disease transmission rate. ...

journal_title：Malaria journal

authors： Galinsky K,Valim C,Salmier A,de Thoisy B,Musset L,Legrand E,Faust A,Baniecki ML,Ndiaye D,Daniels RF,Hartl DL,Sabeti PC,Wirth DF,Volkman SK,Neafsey DE

更新日期：2015-01-19 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) largely account for the scale-up of malaria diagnosis in endemic settings. However, diversity in labelling including the instructions for use (IFU) limits their interchangeability and user-friendliness. Uniform, easy to follow and consistent labelling, aligned with international...

journal_title：Malaria journal

authors： Jacobs J,Barbé B,Gillet P,Aidoo M,Serra-Casas E,Van Erps J,Daviaud J,Incardona S,Cunningham J,Visser T

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Control of mosquitoes requires the ability to evaluate new insecticides and to monitor resistance to existing insecticides. Monitoring tools should be flexible and low cost so that they can be deployed in remote, resource poor areas. Ideally, a bioassay should be able to simulate transient contact between mo...

journal_title：Malaria journal

authors： Sternberg ED,Waite JL,Thomas MB

更新日期：2014-12-16 00:00:00

abstract：BACKGROUND:There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in vitro. However, they are inflammatory and alter the permeability of the blood-brain barrier, rai...

journal_title：Malaria journal

authors： Recuenco FC,Takano R,Chiba S,Sugi T,Takemae H,Murakoshi F,Ishiwa A,Inomata A,Horimoto T,Kobayashi Y,Horiuchi N,Kato K

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...

journal_title：Malaria journal

authors： Verma G,Surolia N

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Dihydroartemisinin (DHA) is a component of artemisinin-based combination therapy (ACT), which is widely recommended for treatment of uncomplicated falciparum malaria. DHA is also the main metabolite of artemether and artesunate, both of which are used in ACT. Due to auto-induction metabolism, declining plasm...

journal_title：Malaria journal

authors： Zang M,Zhu F,Zhao L,Yang A,Li X,Liu H,Xing J

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

journal_title：Malaria journal

authors： Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Intermittent preventive treatment in pregnancy (IPTp) delivered during antenatal care (ANC) visits has been shown to be a highly efficacious and cost-effective intervention. Given the high rates of ANC attendance in sub-Saharan Africa, the current low IPTp coverage represents considerable missed opportunitie...

journal_title：Malaria journal

authors： Maheu-Giroux M,Castro MC

更新日期：2014-11-20 00:00:00

abstract：BACKGROUND:Intensified efforts are urgently needed to contain and eliminate artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion. Médecins Sans Frontières plans to support the Ministry of Health in eliminating P. falciparum in an area with artemisinin resistance in the north-east of Cambodia. As ...

journal_title：Malaria journal

authors： Bosman P,Stassijns J,Nackers F,Canier L,Kim N,Khim S,Alipon SC,Chuor Char M,Chea N,Dysoley L,Van den Bergh R,Etienne W,De Smet M,Ménard D,Kindermans JM

更新日期：2014-10-06 00:00:00